selective,blood-brain barrier — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T12877L	Seltorexant	JNJ-42847922	OX Receptor
	Seltorexant (JNJ-42847922) crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain. Seltorexant is a high-affinity and selective orexin-2 receptor antagonist (pKi: 8.0 and 8.1 for human a...		OX Receptor
T20570	Labetalol	Apo-Labetalol,Albetol,Trandate,Dilevalol,Normodyne	Adrenergic Receptor
	Labetalol (Apo-Labetalol) is a mixed alpha/beta-adrenergic antagonist.It is used to treat high blood pressure. It can be given by mouth for long term hypertension management or intravenously in severe hypertensive situat...		Adrenergic Receptor
T17211	Vafidemstat	ORY-2001	Histone Demethylase , MAO
	Vafidemstat (ORY-2001) is a selective, orally active lysyl-histone demethylase (LSD1)/MAO-B inhibitor that crosses the blood-brain barrier for the study of neurological diseases.		Histone Demethylase , MAO
T2708	SL327	SL 327,SL-327	MEK , DNA/RNA Synthesis
	SL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 μM/0.22 μM; able to transport through the blood-brain barrier.		MEK , DNA/RNA Synthesis
T10855	CO23		Thyroid hormone receptor(THR)
	CO23 is a blood-brain barrier penetrant and selective TRα agonist and can be used in studies about the regulation of growth and development.		Thyroid hormone receptor(THR)
T9070	ASP2905	ASP-2905	Potassium Channel
	ASP-2905 is a potent and selective inhibitor of potassium channel Kv12.2 encoded by the Kcnh3/BEC1 gene. It can cross the blood-brain barrier and has antipsychotic activities		Potassium Channel
T13423	(1R,2R)-2-PCCA hydrochloride	(1R,2R)-2-PCCA(hydrochloride)	Others
	(1R,2R)-2-PCCA hydrochloride is a potent, selective, and blood-brain-barrier-crossing GPR88 receptor agonist with an EC50 value of 1140 n in striatal membranes of WT mice.(1R,2R)-2-PCCA hydrochloride can be used to study...		Others
T38001	LEI-401	LEI 401	Phospholipase
	LEI-401 is a selective and potent NAPE-PLD inhibitor that crosses the blood-brain barrier (IC50: 27 nM).LEI-401 reduces the level of n-acylethanolamines (NAEs) in the brain of free-ranging mice and modulates their emotio...		Phospholipase
T79213	AZD4747		Ras
	AZD4747 is a selective and potent inhibitor of the mutant GTPase KRASG12C that crosses the blood-brain barrier and has potential antitumor activity for the study of pancreatic and colorectal adenocarcinoma.		Ras
T67764	HMAO-B-IN-4		MAO
	hMAO-B-IN-4 is a selective, reversible and blood–brain barrier (BBB) penetrable inhibitor of human monoamine oxidase-B (hMAO-B, IC50=0.067 μM, Ki= 0.03 μM, hMAO-A, IC50= 33.82 μM).		MAO
T16489	Darigabat	CVL-865,PF-6372865,PF-06372865	GABA Receptor
	Darigabat (PF-06372865) is an orally active and selective GABAA receptor modulator that crosses the blood-brain barrier and exhibits anxiolytic activity, with Ki values of 2.9 nM, 21 nM, and 134 nM for α2, α1 PAM, and α2...		GABA Receptor
T60796	Cholesterol 24-hydroxylase-IN-1
	Cholesterol 24-hydroxylase-IN-1 (compound 17) is a potent, orally active, and highly selective inhibitor of cholesterol 24-hydroxylase (CH24H or CYP46A1) with IC50 of 8.5 nM that can cross blood-brain barrier [1].
T22171	WWL123		MAGL
	WWL123 is a potent and selective ABHD6 inhibitor (IC50=430 nM). WWL123 crosses the blood-brain-barrier and inhibits ABHD6 in brain parenchyma. ABHD6 blockade by WWL123 exerts an antiepileptic effect in Pentylenetetrazole...		MAGL
T10585	Bozitinib	CBT-101,PLB-1001	c-Met/HGFR
	Bozitinib (PLB-1001) (PLB-1001) is a highly selective inhibitor of the c-MET kinase with blood-brain barrier permeability. Bozitinib binds to the conventional ATP-binding pocket of the tyrosine kinase superfamily.		c-Met/HGFR
T10202	A 1070722		GSK-3
	A 1070722 is a potent and selective GSK-3 inhibitor, with a Ki of 0.6 nM for both GSK-3α and GSK-3β. It can penetrate the blood-brain barrier (BBB) and accumulates in brain regions, thus potential for PET radiotracer for...		GSK-3
T39214L	LXE408 fumarate	LXE408 fumarate (1799330-15-6 Free base)	Proteasome
	LXE408 fumarate is an orally active, non-competitive and kinetoplastid-selective proteasome inhibitor. LXE408 fumarate has an IC50 of 0.04 μM for L. donovani proteasome and an EC50 of 0.04 μM for L. donovani. LXE408 fuma...		Proteasome
T9146	Ms48107	Benzenemethanol, 2-[4-amino-6-[[(4-phenoxyphenyl)methyl]amino]-1,3,5-triazin-2-yl]-3-fluoro-	Others
	MS48107 is a potent, selective positive allosteric modulator of G protein-coupled receptor 68 (GPR68), demonstrating specificity for GPR68 over closely related proton GPCRs, neurotransmitter transporters, and hERG ion ch...		Others
T16962	SW-100		HDAC
	SW-100 is a selective histone deacetylase 6 inhibitor (IC50: 2.3 nM). It also shows at least 1000-fold selectivity for HDAC6 relative to all other HDAC isozymes. SW-100 displays an obviously improved ability to cross the...		HDAC
T72953	Zidesamtinib	NVL-520	ROS Kinase
	Zidesamtinib (NVL-520) is an orally active, selective, potent, and blood-brain-barrier-crossing inhibitor of ROS1 fusion and resistance mutations, inhibits ROS1 and ROS1 G2032R, and can be used in the study of non-small-...		ROS Kinase
T61934	Repinotan
	Repinotan (BAY x 3702 free base) is an effective, selective, blood-brain barrier permeable, oral active 5-HT1A receptor agonist. The Ki values of Repinotan are 0.19 nM (calf hippocampus), 0.25 nM (rat and human cortex) a...